Gene Traffic ControlTM
At an airport, air traffic control directs hundreds of planes on when, where, and in what order they should move. If the control tower’s communication broke down, the result would be catastrophic.
Like at the airport, our cells need a system to direct when, where, and in what order our genes are expressed. In other words, this system, called the chromatin regulatory system, orchestrates the events that turn genes “on” and “off.”
With Gene Traffic ControlTM, Foghorn has developed a platform to precisely target and drug issues in this master regulatory system.
Breakdown in this system is a major, unexplored cause of many serious diseases, including over 25% of cancers.
From Chromatin to
For human DNA to fit within our cells, it’s compacted and packaged in the nucleus of the cell as a substance called chromatin. For our genes to be expressed, the chromatin needs to be opened up so our DNA’s instructions can be read. The chromatin regulatory system is responsible for the opening and closing of this chromatin, and hence impacts which genes express certain traits.
A New and Powerful
Foghorn has a broad platform based on the biology of the chromatin regulatory system. With our powerful Gene Traffic ControlTM (GTC) platform, we are harnessing our knowledge of this system to develop medicines.
Foghorn has already used the GTCTM platform to develop new insights, rapidly advance multiple programs, and create a discovery engine that will simultaneously yield many additional targets. With insight from our scientific founders, seasoned board and leadership team, and discovery engine, this is just the beginning of an entirely new approach to regulate gene expression.